Endocrine Abstracts

Introduction: Gas chromatography tandem mass spectrometry (GC-MS/MS) quantitatively detects a large number of steroids at one time in a single serum sample. Most studies of subclinical hypercortisolism in adrenal incidentalomas have focused on detection of a few steroids like cortisol, DHEA/S, androstenedione, testosterone. We used GC-MS/MS to quantify 91 steroids in patients with adrenal incidentalomas to search for the most reliable marker of subclinical hypercortisolism.</p...

Introduction: Gas chromatography tandem mass spectrometry (GC-MS/MS) quantitatively detects many steroids at one time in a single serum sample. Cushing’s syndrome (CS) caused by adrenal adenoma is often associated with decreased DHEAS, whereas low levels of aldosterone in ACTH dependent CS and also low levels of 18-oxocortisol were observed in ectopic CS. We aimed to evaluate steroid differences in various types of CS.Methods: In serum from patients...